Monday, November 23, 2009

Portal Hypertension

Anatomy of the portal system :


The portal vein is formed behind the neck of pancreas, at the level of L2, by the superior mesenteric and splenic veins.
It ascends up along the free edge of lesser omentum, behind the common bile duct.
It enters the liver by dividing into two of it's tributaries.
The left and right gastric veins joins to it.
The inferior mesenteric veins drains into the splenic veins.
Portal vein is valveless and hence, if there's a raised in pressure in between the right heart and the splanchnic circulation, portal pressure elevates.
The portal vein carries about 1.5L of blood per minute, originating from :

Small bowel (superior mesenteric vein)
Large bowel (inferior mesenteric vein)
Spleen (Splenic vein)
Gastric vein

Pathophysiology

Normal portal pressure is about 5-10mmHg.
Portal hypertension occurs when the portal pressure elevates beyond 12mmHg.
At this point, the collaterals at sites of porto-systemic anastomosis opens up in order to decompress the elevated pressure in the portal system.
As the portal pressure elevates above 20mmHg, there's a risk of the friable, submucosal esophageal varices to rupture, causing massive hematemesis.

Sites of porto-systemic anastomosis :


1) Between left and short gastric veins (portal) and azygous veins (systemic) at the lower esophagus and stomach

2) Caput medusae : Paraumbilical veins (systemic) and vein within the ligamentum teres (portal)

3) Lower rectum : Superior and middle haemorrhoidal veins (portal) and inferior haemorrhoidal veins (systemic)

4) Perihepatic veins of Sappey : Subdiagphramatic veins (portal) and Veins at the upper surface of right liver lobe (systemic)

5) Retroperitoneal veins of Retzius : Retroperitoneal veins (systemic) and Superior + Inferior mesenteric veins (portal)

Causes :


a) Pre-hepatic Causes :

Portal vein thrombosis - seen in umbilical sepsis (infants)
Splenic vein thrombosis - Complication of pancreatitis, pancreatic tumour

b) Intrahepatic Causes :

i) Pre-sinusoidal :

Schistosomiasis
Primary biliary cirrhosis
Chronic active hepatitis
Sarcoidosis

ii) Sinusoidal :

Cirrhosis
Cytotoxic drugs
Vitamin A intoxication

iii) Post-sinusoidal :

Cirrhosis
Veno-occlusive diseases

c) Post-hepatic causes :

Budd-Chiari's syndrome
Tricuspid regurgitation
Constrictive Pericarditis

Clinical presentation (History and Examination)

Malnutrition
Ascites
Hematemesis and Malena
Encephalopathy
Caput medusae
Splenomegaly
Venous hum heard
Look for signs and symptoms of chronic liver disease

How do you manage these patients?

1) Esophageal varices without prior h/o of bleeding

Medical management is ideal in such cases.
Start Propanolol orally to reduce portal pressure, provided that there's no contraindication against B-blockers.
If contraindication present, isosorbide-5-mononitrate is an alternative.
Studies have shown that B-blockers reduces 45% of the risk of bleeding.

2) Ruptured esophageal varices presented with hematemesis

95% of the cases - originating from the esophageal varices, 5% - gastric origin
First, assess the rate and volume of bleeding :

Take pulse and BP in standing and sitting position
Gain IV ascess - Blood is withdrawn for hematocrit, coagulation profile, LFT and BUSE, blood grouping and cross matching
Provide immediate fluid resuscitation (Crystalloids, colloids, or even blood transfusion)
Insert CVP line - for ease of rapid transfusion later to prevent volume overload



Start Vasopressin IV (Contraindicated in angina) or Somastostatin IV.
Or Octreotide IV (more potent and duration of action is longer)

Usually 3 days later, as the patient's condition has stabilised, start B-blocker to reduce portal pressure and prevent further bleeding.

Plan for endoscopic treatment :

a) Band ligation
b) Sclerotherapy (Sodium Tetradecyl Sulphate - STS)



If the patient is not reponsive to the above measures and still bleeding or endoscopic intervention is not available (district hospitals), a Sangstaken-Blakemore tube can be inserted to prevent bleeding to buy time for deciding what's the next step. (Shoiuld be removed after 48 hrs)



Start oral neomycin (to reduce bowel flora -> less conversion of nitrogenous waste within bowel back to ammonia -> prevent hyperammonemia)
Start lactulose (to reduce bowel transit time)
Repeat every 2 weeks the sclerotherapy/band ligation until all the varices have been treated.

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